Dendrimers as Novel Nano-Sized Vectors for Drug and Gene Delivery
Dendrimer macromolecules, characterized by regular branching with radial symmetry, represent a unique class of polymers with numerous potential applications in technology and medicine. In particular, polyamidoamine (PAMAM) dendrimers, being protonated under physiological conditions, represent a promising class of nonviral, nanosized vectors for drug and gene delivery due to their high surface charge and ability to adapt conformation in response to changes in their surrounding environment. Given the exceptional potential of the dendritic polymers, our studies focus on coarse-grained molecular dynamics simulations of cationic dendrimers and their complexes with oppositely charged linear polyelectrolytes.
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