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Complexes of DNA with Cationic Polymers


One of the widely used types of non-viral gene delivery vehicles is a vector based on synthetic cationic polymers: DNA, being a polyanionic molecule, forms stable supramolecular complexes with oppositely charged, cationic polymers. Our studies focus on formation of complexes between DNA and cationic polymers as well as on the atomistic structures of resulting supramolecular complexes. A wide range of cationic polymers is considered to explore sensitivity of DNA-polymer complexes to the chemical structure of polycations.

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